|
KMID : 0613820200300060542
|
|
Journal of Life Science
2020 Volume.30 No. 6 p.542 ~ p.549
|
|
|
Study of in Vivo Serum Lipid Regulation with Ulmus macrocarpa Hance Extract in Rats
|
|
Hwang Mi-Sun
Kim Tae-Hee
Lee Jeong-Jun
Kwon Jung-Kee
Lee Jin-Young
|
|
|
Abstract
|
|
|
|
A previous study reported that Ulmus macrocarpa Hance water extract (UME) can improve hyperlipid metabolism and the involvement of suppressed lipid synthesis through adenosine monophosphate -activated protein kinase (AMPK) pathway regulation was suggested. Further exploration of the lipid metabolism between liver and peripheral tissue was necessary to confirm that work, and so this study aimed to extend the possibility that UME can regulate serum lipids. After a 6-week in vivo trial of oral administration of UME to rats with induced hyperlipidemia, serum levels of triglyceride (TG) and total cholesterol (TC) were seen to decrease while HDL cholesterol increased. The UME administrations also decreased the TC and TG levels from the control in liver analysis. However, the suggestion that UME regulates the AMPK pathway to improve hyperlipid states through the suppression of hepatic lipogenesis seems to be only one part of the extract’s effect. Indeed, serum concentrations of apolipoproteins A and B were returned to baseline levels of the control group in response to UME administration whilst the liver lipid content was much reduced; this cannot occur through the suggested suppression of hepatic lipogenesis alone. Therefore, a possible mechanism of UME could be that it improves blood circulation by modulating serum lipid levels through both the prior stimulation of lipid oxidation and the suppression of hepatic lipogenesis.
|
|
|
KEYWORD
|
|
|
Apolipoprotein A, Apolipoprotein B, hyperlipidemia, lipid metabolism, Ulmus macrocarpa Hance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|